Breast and Colon Cancer Family Registries

For Research Collaborators: Scientific Session

Breast and Colon Cancer Family Registry Scientific Session
Monday, December 5, 2005
Bethesda, Maryland

Welcome and NCI Introduction Daniela Seminara, Ph.D., M.P.H., Program Director, Division of Cancer Control and Population Sciences, National Cancer Institute
Robert Croyle, Ph.D., Director, Division of Cancer Control and Population Sciences, National Cancer Institute
Introduction Ed Trapido, Ph.D., Sc.D., Associate Director, Epidemiology and Genetics Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute

Colon Cancer Family Registry (CFR) Research Updates
Introduction and Overview of Colon Cancer Family Registry (CFR) Research Robert Haile, Dr.P.H., Professor/Director, Genetic Epidemiology Program, Keck School of Medicine, University of Southern California
	Mismatch Repair (MMR) Gene-Related Research
	Guanosine Monophosphate (GMP) Study Graham Casey, Ph.D., Staff, Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic Foundation
	Amsterdam Study Laney Lindor, M.D., Associate Professor of Medical Genetics, Mayo Clinic Postmeiotic Segregation Increased 2 (PMS2) Study Laney Lindor, M.D., Associate Professor of Medical Genetics, Mayo Clinic
	MutS Homolog 6 (MSH6) Study Steve Thibodeau, Ph.D., Lab Director, Laboratory Genetics, Mayo Clinic Multiple Ligation-Dependent Probe Amplification (MLPA) Study Steve Thibodeau, Ph.D., Lab Director, Laboratory Genetics, Mayo Clinic
	Pathology/Bethesda Criteria Jeremy Jass, M.D., Professor, Pathology Department, McGill University
	Mismatch Repair (MMR) Penetrance Mark Jenkins, Ph.D., Senior Lecturer, Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, The University of Melbourne
Metabolic Pathways John Potter, M.D., Ph.D., Senior Vice President and Director, Public Health Sciences, Fred Hutchinson Cancer Research Center
Modeling Approaches to Metabolic Pathways Duncan Thomas, Ph.D., Professor Co-Director Biostatistics Division, Keck School of Medicine, University of California
Ontario Myosin Heavy Chains (MYH) Analysis and CFR-wide Preliminary Data Steve Gallinger, M.D., Principal Investigator, Ontario Colon CFR, Ontario Familial Colorectal Cancer Registry, Mount Sinai Hospital, University of Toronto
CpG Island Methylator Phenotype (CIMP) and Methylation Research Peter Laird, Ph.D., Associate Professor, University of Southern California
Collaborations With the Cancer Family Registry (CFR) on the Pathogenesis of Syndrome X C. Richard Boland, M.D., Chief, Division of Gastroenterology, Baylor University Medical Center
Studies in Transforming Growth Factor beta (TGF-beta) Pathways (Breast and Colon) Boris Pasche, M.D., Ph.D., FACP, Director, Cancer Genetics Program, Department of Hematology/Oncology, Northwestern University Feinberg School of Medicine

Joint Genomewide Association Studies
Overview of Analytical Methods Duncan Thomas, Ph.D. (pictured above), Professor Co-Director Biostatistics Division, Keck School of Medicine, University of California
Breast Cancer Family Registry (CFR) Genomewide Association Project Habib Ahsan, M.D., M.Med.Sc., Associate Professor/Director, Center for Genetics in Epidemiology, Mailman School of Public Health, Columbia University
Colon Cancer Family Registry (CFR) Genomewide Association Project Graham Casey, Ph.D. (pictured above), Staff, Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic Foundation
Assessment of Risk for Colorectal Tumors (ARCTIC) Brent Zanke, M.D., Ph.D., FRCPC, Provincial Head, Systemic Therapy, Vice President, Ontario Cancer Research Network, Cancer Care Ontario & Ontario Cancer Research Network

Breast Cancer Family Registry (CFR) Research Updates
Introduction and Overview of Research Irene Andrulis, Ph.D., Director, Ontario Cancer Genetics Network, Cancer Care Ontario
Cancer Risks in Relatives of Patients With Breast or Ovarian Cancer Alice Whittemore, Ph.D., Professor, School of Medicine, Stanford University
Minority Families in the Breast Cancer Family Registry—Resources and Ongoing Research Esther John, Ph.D., Research Scientist, Department of Epidemiology, Northern California Cancer Center
Ethnocultural Study Mary Daly, Ph.D., Director, Cancer Prevention and Control, Fox Chase Cancer Center
Breast Cancer Histopathologic Phenotype and Biomarker Frances O'Malley, M.D., Department of Pathology, Mount Sinai Hospital
Mutations in Cytochrome P450c17alpha gene (CYP17) and Other Hormone Metabolism Genes and Risk of Breast Cancer John Hopper, Ph.D., M.Sc., Director, Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, The University of Melbourne
Breast Cancer 1 Gene (BRCA1) and Breast Cancer 2 Gene (BRCA2) Mutation Screening in the Breast Cancer Family Registry (CFR) Melissa Southey, Ph.D., Scientist, International Agency for Research on Cancer
Epidemiologic Risk Factor and Tumor Characteristics Mary Beth Terry, Ph.D., Assistant Professor, Columbia University
Checkpoint Kinase 2 (CHEK2) and Ataxia-Telangiectasia Mutated Gene (ATM) Jonine Bernstein, Ph.D., Associate Attending Epidemiologist, Department of Epidemiology, Memorial Sloan-Kettering Cancer Center
Smoking and Risk of Breast Cancer in Carriers Norman Boyd, M.D., D.Sc., FRCPC, Senior Scientist, Ontario Cancer Institute
Alcohol Gene-Environmental Study Julia Knight, Ph.D., Investigator, Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Bioinformatics Applications for Breast and Colon Cancer Family Registries (BC-CFR) David Hall, Ph.D., Bioinformatician, Research Triangle Institute